UKM 2016 - Prof. Walter Stummer und Team

13335

12.07.17

PhD student in biochemistry, chemistry or biology (m/f)

In the Institute for Physiological Chemistry and Pathobiochemistry of the University of Münster, Germany we are looking for a

PhD student in biochemistry, chemistry or biology (m/f)
Ref.: 13335


TV-L13/2 Research Scientist

The position is available for 3 years from September 1st, 2017, for the completion of a PhD in the Institute for Physiological Chemistry and Pathobiochemistry of the University of Münster, Germany.

We offer an excellent biochemical, molecular- and cell-biological research environment with international and national collaborations, especially with other redox biology researchers of the SPP1710.

We expect a motivated person with skills in molecular biology and cell biology, protein chemistry and cell biology. The candidate should be willing to learn new methods and technologies. The project focuses on redox regulation of cell-extracellular matrix-interactions. Established methods of redox biology will be employed to assess the changes in protein oxidation as a cause or consequence of cell-matrix contacts. Preferred cell systems are melanoma cells, which will be embedded as spheroids in three-dimensional gel culture systems. The major focus is on the adhesion receptors of the integrin family, their redox biological regulation and effect on cell adhesion, migration and invasion. The role of redoxins and matrix-degrading enzymes (MMPs) will be analyzed together with cooperation partners of the DFG-financed SPP1710 consortium.


We expect the applicant to exchange with cooperating labs within Germany and to participate in workshops and meetings of the consortium.The daily language in the laboratory is English, but applicants are encouraged to learn German.

The applicant will perform the following tasks:

  • Molecular biological preparation of expression vectors and transfection of eukaryotic cell lines
  • Preparation of melanoma cell spheroids and culturing them in three-dimensional gel cultures
  • Detection of reactive oxygen species, hypoxia and cysteine-oxidized proteins in spheroids by immunofluorescence, life cell microscopy, and protein chemical methods (e.g. modification reactions, immunoblots)
  • Protein chemical analysis, e.g. of MMP-cleaved matrix proteins
  • Cell adhesion and migration studies

For further information please contact Prof. Dr. Eble.

Please direct your application electronically as a single pdf-file to bewerbung(at)­ukmuenster(dot)­de and to Prof. Dr. Johannes A. Eble/Frau Holtkötter (E-mail: holtkel(at)­uni-muenster(dot)­de) no later than August 1st, 2017 and by giving the reference number 13335.

Applications of women are specifically invited. In the case of similar qualifications, competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities. Handicapped candidates with equivalent qualifications will be given preference.

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