Klinik für Neurochirurgie

Publikationen

2017

Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma. Neuro Oncol. 2017 Nov 7. doi:10.1093/neuonc/nox204. [Epub ahead of print]
Schäfer N, Proescholdt M, Steinbach JP, Weyerbrock A, Hau P, Grauer O, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Grau S, Hänel M, Schnell O, Krex D, Vajkoczy P, Tabatabai G, Mack F, Schaub C, Tzaridis T, Nießen M, Kebir S, Leutgeb B, Urbach H, Belka C, Stummer W, Glas M, Herrlinger U.

Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro Oncol. 2017 Aug 21. doi:10.1093/neuonc/nox155. [Epub ahead of print]
Dagmar D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs S, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H,
Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann RD, Bogdahn U, Hau P.

Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery-review of the literature. Neurosurg Rev. 2017 Sep 18. doi: 10.1007/s10143-017-0907-z.
[Epub ahead of print] Review.
Suero Molina E, Schipmann S, Stummer W.

Regression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review. World Neurosurg. 2017 Aug 24. pii:S1878-8750(17)31407-9. doi:10.1016/j.wneu.2017.08.106. [Epub ahead of print] Review.
Schipmann S, Keurhorst D, Köchling M, Schwake M, Heß K, Sundermann B, Stummer W, Brentrup A.

Fluorescence Imaging/Agents in Tumor Resection. Neurosurg Clin N Am. 2017 Oct;28(4):569-583. doi: 10.1016/j.nec.2017.05.009. Epub 2017 Aug 18.
Stummer W, Suero Molina E.

Multimodal Imaging of Patients With Gliomas Confirms (11)C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy. Mol Imaging. 2017 Jan 1;16:1536012116687651. doi:10.1177/1536012116687651.
Laukamp KR, Lindemann F, Weckesser M, Hesselmann V, Ligges S, Wölfer J, Jeibmann A, Zinnhardt B, Viel T, Schäfers M, Paulus W, Stummer W, Schober O, Jacobs AH.

Illumination in Spinal Surgery Depending on Different Approaches and Light Sources. World Neurosurg. 2017 Sep;105:585-590. doi: 10.1016/j.wneu.2017.06.013. Epub 2017 Jun 9.
Wilbers E, Ewelt C, Schipmann S, Stummer W, Klingenhöfer M.

Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report. Case Rep Oncol. 2017 Apr 18;10(1):350-355. doi: 10.1159/000470832.
Naydenov E, Minkin K, Penkov M, Nachev S, Stummer W.

The Simpson grading in meningioma surgery: does the tumor location influence the prognostic value? J Neurooncol. 2017 Jul;133(3):641-651. doi: 10.1007/s11060-017-2481-1. Epub 2017 May 19.
Voß KM, Spille DC, Sauerland C, Suero Molina E, Brokinkel C, Paulus W, Stummer W, Holling M, Jeibmann A, Brokinkel B.

Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery-review of the literature.
Neurosurg Rev. 2017 Sep 18.
Suero Molina E, Schipmann S, Stummer W.

Fluorescence Imaging/Agents in Tumor Resection.
Neurosurg Clin N Am. 2017 Oct;28(4):569-583. doi: 10.1016/j.nec.2017.05.009. Epub 2017 Aug 18.
Stummer W, Suero Molina E.

Letter: Brain Invasion in Meningiomas-Sex-Associated Differences are not Related to Estrogen-
and Progesterone Receptor Expression.
Neurosurgery. 2017 Apr 5.
Heß K, Spille DC, Wagner A, Stummer W, Paulus W, Brokinkel B.

Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for
Fluorescence-Guided Resections of Malignant Gliomas. Neurosurgery. 2017
Stummer W, Stepp H, Wiestler OD, Pichlmeier U.

Endoscopic management of a low-grade thalamic glioma: a safe alternative to open microsurgery? Acta Neurochir (Wien). 2017 Feb 24.
Brokinkel B, Yavuz M, Warneke N, Brentrup A, Hess K, Bleimüller C, Wölfer J,
Stummer W.

Intra-operative tissue diagnosis: isn't it time for some reporting guidelines?
Acta Neurochir (Wien). 2017 Feb;159(2):369-370.
Stummer W.

Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
J Neursurgery, 2017 Mar 24
Suero Molina E, Wölfer J, Ewelt C, Ehrhardt A, Brokinkel B, Stummer W.

2016

Computed Tomographic Blend Sign Is associated With Computed Tomographic Angiography Spot Sign and Predicts Secondary Neurological Deterioration After Intracerebral Hemorrhage.
Stroke. 2016 Nov 22
Sporns PB, Schwake M, Schmidt R, Kemmling A, Minnerup J, Schwindt W, Cnyrim C, Zoubi T, Heindel W, Niederstadt T, Hanning U.

5-ALA Fluorescence in Native Pituitary Adenoma Cell Lines: Resection Control and Basis for Photodynamic Therapy (PDT)?
PLoS One. 2016 Sep 1;11(9)
Nemes A, Fortmann T, Poeschke S, Greve B, Prevedello D, Santacroce A, Stummer W, Senner V, Ewelt C.

When the infection hits the wound - Matched case-control study in a neurosurgical patient collective including systematic literature review and risk factors analysis.
World Neurosurg. 2016 Aug 6.
Schipmann S, Akalin E, Doods J, Ewelt C, Stummer W, Suero EJ.

hTERT promoter methylation in meningiomas and central nervous hemangiopericytomas.
J Neurooncol. 2016 Jul 27.
Fürtjes G, Köchling M, Peetz-Dienhart S, Wagner A, Heß K, Hasselblatt M, Senner V, Stummer W, Paulus W, Brokinkel B.

Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients.
J Neurosurg. 2016 Jun 3:1-11.
Brokinkel B, Holling M, Spille DC, Heß K, Sauerland C, Bleimüller C, Paulus W, Wölfer J, Stummer W.

Long-term survival following additive radiotherapy in patients with atypical
teratoid rhabdoid tumors.
Strahlenther Onkol. 2016 Aug;192(8):569-581. Epub 2016 Jun 7.
Elsayad K, Kriz J, Samhouri L, Haverkamp U, Straeter R, Stummer W, Eich HT.

Brain Invasion in meningiomas: Incidence and correlations with clinical variables and prognosis.
World Neurosurg. 2016 Jun 22.
Spille DC, Heß K, Sauerland C, Sanai N, Stummer W, Paulus W, Brokinkel B.

Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.
J Clin Oncol. 2016 Mar 14.
Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Maciaczyk J, Grau S, Schnell O, Hänel M, Krex D, Vajkoczy P, Gerlach R, Kortmann RD, Mehdorn M, Tüttenberg J, Mayer-Steinacker R, Fietkau R, Brehmer S, Mack F, Stuplich M, Kebir S, Kohnen R, Dunkl E, Leutgeb B, Proescholdt M, Pietsch T, Urbach H, Belka C, Stummer W, Glas M.

Intraoperative myelography of traumatic spine injury in patients with ankylosing spondylitis.
Technical note. Acta Neurochir (Wien). 2016 Apr;158(4):745-8.
Schwake M, Zoubi T, Ewelt.

Factors confounding fluorescein-guided malignant glioma resections:
edema bulk flow, dose, timing, and now: imaging hardware?
Acta Neurochir (Wien).2016 Feb;158(2):327-8.
Stummer W.

Commentary: Combining 5-Aminolevulinic Acid Fluorescence and
Intraoperative Magnetic Resonance Imaging in Glioblastoma Surgery: A
Histology-Based Evaluation.
Neurosurgery. 2016 Apr;78(4):484-6.
Stummer W.

hTERT promoter methylation in pituitary adenomas.
Brain Tumor Pathol. 2016 Jan;33(1):27-34.
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M,
Paulus W, Stummer W, Brokinkel B.

The Value of 5-Aminolevulinic Acid in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features: An Analysis Based on Fluorescence, Magnetic Resonance Imaging, 18F-Fluoroethyl Tyrosine Positron Emission Tomography, and Tumor Molecular Factors.
Neurosurgery. 2016 Mar;78(3)
Jaber M, Wölfer J, Ewelt C, Holling M, Hasselblatt M, Niederstadt T, Zoubi T, Weckesser M, Stummer W.

Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
J Neurosurg. 2016 Jan;124(1):51-8.
Ehlert A, Schmidt C, Wölfer J, Manthei G, Jacobs AH, Brüning R, Heindel W,
Ringelstein EB, Stummer W, Pluta RM, Hesselmann V.

ADAMTS genes and the risk of cerebral aneurysm.
J Neurosurg. 2016 Jan 8:1-6
Arning A, Jeibmann A, Köhnemann S, Brokinkel B, Ewelt C, Berger K, Wellmann J, Nowak-Göttl U, Stummer W, Stoll M, Holling M.

2015

Factors confounding fluorescein-guided malignant glioma resections: edema bulk flow, dose, timing, and now: imaging hardware?
Acta Neurochir (Wien). 2015 Dec 7.
Stummer W.

CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.
Neuro Oncol. 2015 Nov 17.
Dubinski D, Wölfer J, Hasselblatt M, Schneider-Hohendorf T, Bogdahn U, Stummer W, Wiendl H, Grauer OM.

Commentary: Combining 5-Aminolevulinic Acid Fluorescence and Intraoperative Magnetic Resonance Imaging in Glioblastoma Surgery: A Histology-Based Evaluation.
Neurosurgery. 2015 Nov 6.
Stummer W.

hTERT promoter methylation in pituitary adenomas.
Brain Tumor Pathol. 2015 Sep 21.
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M, Paulus W, Stummer W, Brokinkel B. 

Fluorescein in brain metastasis and glioma surgery.
Acta Neurochir (Wien). 2015 Dec;157(12):2199-200.
Stummer W.

The Value of 5-ALA in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features: An Analysis Based on Fluorescence, MRI, 18F-FET PET, and Tumor Molecular Factors.
Neurosurgery. 2015 Sep 11.
Jaber M, Wölfer J, Ewelt C, Holling M, Hasselblatt M, Niederstadt T, Zoubi T, Weckesser M, Stummer W.

What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?
Neurosurgery. 2015 Nov; 77(5):663-73.
Hadjipanayis CG, Widhalm G, Stummer W.

Altered inhibition in the hippocampal neural networks after spreading depression.
Neuroscience. 2015 Jul 23;304:190-197.
Mesgari M, Ghaffarian N, Khaleghi Ghadiri M, Sadeghian H, Speckmann EJ, Stummer W, Gorji A.

Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature.
J Photochem Photobiol B. 2015 Jul;148:302-9.
Ewelt C, Nemes A, Senner V, Wölfer J, Brokinkel B, Stummer W, Holling M. 

Poor man's fluorescence?
Acta Neurochir (Wien). 2015 Sep;157(8):1379-81.
Stummer W.

Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
 J Neurosurg. 2015 Jul 10:1-8.
Ehlert A, Schmidt C, Wölfer J, Manthei G, Jacobs AH, Brüning R, Heindel W, Ringelstein EB, Stummer W, Pluta RM, Hesselmann V. 

δ-Aminolevulinic acid-induced fluorescence-guided resection of brain tumors.
 Neurol India. 2015 Mar-Apr;63(2):155-65.
Moiyadi AV, Stummer W.

Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines.
Int J Mol Sci. 2015 Apr 30;16(5):9936-48.
El-Khatib M, Tepe C, Senger B, Dibué-Adjei M, Riemenschneider MJ, Stummer W, Steiger HJ, Cornelius JF. 

Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery.
Acta Neurochir (Wien). 2015
Schwake M et al.

A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery.
Neurosurgery. 2015
Esteves S et al.

Proconvulsive effect of hydrochlorothiazide in an in vitro rat seizure model.
Iran J Basic Med Sci. 2014
Kellinghaus C et al

Response to journal club: 5-aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging.
Neurosurgery. 2015
Stummer W

Teaching the concept of brain death in undergraduate medical education.
J Surg Educ. 2015
Holling M et al

CENTER-TBI Participants and Investigators. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury
(CENTER-TBI): a prospective longitudinal observational study.
Neurosurgery. 2015
Maas AI et al

5-ALA Glioma Study Group. Anatomic features of glioblastoma and their potential impact
on survival.
Acta Neurochir (Wien). 2015
Nestler U et al.

Cognitive impairments and neuronal injury in different brain regions of a genetic rat model of absence epilepsy.
Neuroscience. 2015
Jafarian M et al.

Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats.
Neuropeptides. 2015
Sajadian A et al

Surgical treatment of lumbosacral pseudarthrosis and spondyloptosis in a patient with neurofibromatosis type 1 and a large lumbar
anterior meningocele. Case report and review of the literature.
J Neurol Surg A Cent Eur Neurosurg. 2015
Brokinkel B, et al.

A comparative analysis of MAPK pathway hallmark alterations in pilocytic astrocytomas: age-related and mutually exclusive.[corrected].
Neuropathol Appl Neurobiol. 2015
Brokinkel B, et al.

2014

Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine.
Suero Molina EJ, et al. J Neurosurg Spine 2014

Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey.
Stummer W, et al. Acta Neurochirur (Wien). 2014

Gamma Knife radiosurgery following subtotal resection provides tumor growth control and excellent clinical outcomes in vestibular schwannoma.
Brokinkel B, et al. J Clin Neurosci. 2014

Glioma Tissue Obtained by Modern Ultrasonic Aspiration with a Simple Sterile Suction Trap for Primary Cell Culture and Pathological Evaluation.
Schroeteler J, et al. Eur Surg Res. 2014

[Interdisciplinary neuro-oncology : Part 2: systemic therapy of primary brain tumors.]
Tabatabai G, et al. Nervenarzt. 2014.

[Interdisciplinary neuro-oncology : Part 1: diagnostics and operative therapy of primary brain tumors.]
Tabatabai G, et al. Nervenarzt. 2014.

Predictive chromosomal clusters of synchronous and metachronous brain metastases in clear cell renal cell carcinoma.
Gutenberg A, et al. Cancer Genet. 2014

Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
Wilbers E, et al.
Acta Neurochir (Wien). 2014

Surgical Treatment of Lumbosacral Pseudarthrosis and Spondyloptosis in a Patient with Neurofibromatosis Type 1 and a Large Lumbar Anterior Meningocele. Case Report and Review of the Literature.
Brokinkel B, Schroeteler J, Kasprzak B, Brentrup A, Ewelt C, Stummer W, Klingenhoefer M.
J Neurol Surg A Cent Eur Neurosurg. 2014 May 12.

Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid.
Schwake M, Günes D, Köchling M, Brentrup A, Schroeteler J, Hotfilder M, Fruehwald MC, Stummer W, Ewelt C
Acta Neurochir (Wien). 2014 Apr 29.

A comparative analysis of MAPK pathway hallmark alterations in pilocytic astrocytomas: Age-related and mutually exclusive.
Brokinkel B, Peetz-Dienhart S, Ligges S, Brentrup A, Stummer W, Paulus W, Hasselblatt M
Neuropathol Appl Neurobiol. 2014 Apr 18. doi: 10.1111/nan.12145. [Epub ahead of print]

5-Aminolevulinic Acid-derived Tumor Fluorescence: The Diagnostic Accuracy of Visible Fluorescence Qualities as Corroborated by Spectrometry and Histology and Postoperative Imaging.
Stummer W, Tonn JC, Goetz C, Ullrich W, Stepp H, Bink A, Pietsch T, Pichlmeier U
Neurosurgery. 2014;74(3): 310-20

Evaluation of post-operative complications associated with repeat resection and BCNU wafer implantation in recurrent glioblastoma.
Samis Zella MA, Wallocha M, Slotty PJ, Isik G, Hänggi D, Schroeteler J, Ewelt C, Steiger HJ, Sabel M
Acta Neurochir (Wien). 2014;156(2): 313-23

Spreading depression triggers activity in partially disinhibited neuronal tissues.
Eickhoff M, Kovac S, Shahabi P, Khaleghi Ghadiri M, Dreier JP, Stummer W, Speckmann EJ, Pape HC, Gorji A
Exp Neurol. 2014;253: 1-15